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Early treatment may have a favorable result but response to treatment is usually poor, as the disease becomes irreversible in its later stages

Some sources of ROS formation and transformation are schematically outlined in Fig

Following cDNA synthesis the samples were diluted 1:5 with nuclease free H 2 O for use in the PCR reaction using LightCycler 480 SYBR Green I Master mix (Roche) and forward and reverse primers added

Neuroreport 12(11):25312535 Perry T, Greig NH (2005) Enhancing central nervous system endogenous GLP-1 receptor pathways for intervention in Alzheimers disease