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In general, regions of cortical gray matter (parietal, frontal, and temporal) develop earlier in females than in males during adolescence (Giedd et al., 2012)

Nrf2 activity increases in response to oxidative stress and exerts a broad range of transcriptional activity that serves to normalize redox status and decrease inflammation

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However, it is also possible that some subjects may suffer from irreversible damage depending on how severe their dependence was, their previous history of smoking and other factors

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