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Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike protein

120 Sterol CoA desaturase (SCD1) is a lipid regulatory enzyme that catalyzes the desaturation of saturated fatty acids to their 9-monounsaturated counterparts

Esterbauer H, Zollner H (1989) Methods for determination of aldehydic lipid peroxidation products

The first screen thus employed a yeast strain that is a glutathione-deficient yeast where the first enzyme involved in glutathione biosynthesis, -glutamyl-cysteine synthetase (GSH1), is disrupted