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doi:10.1093/clinchem/45.7.1058

FOXO4-DRI and Insulin Signaling In the context of longevity, FOXO4s activities are often linked through the insulin and insulin-like growth factor signaling (IIS) pathway

When formulated together, niacinamides anti-inflammatory and barrier-strengthening properties help improve tolerability of tretinoin, reducing common side effects like dryness and irritation