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DNA damage response is triggered by DNA lesions and is necessary to initiate downstream signaling pathways such as apoptosis, cell cycle arrest, and DNA repair

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Anti-Cancer Drugs 22(9):853863 Yeruva L, Hall C, Elegbede JA, Carper SW (2010) Perillyl alcohol and methyl jasmonate sensitize cancer cells to cisplatin

Trxs play numerous roles, including supplying reducing equivalents to enzymes like ribonucleotide reductase, methionine sulfoxide reductase, etc., selectively activating transcription factors, altering gene transcription, and functioning as cell growth factors, and also as inhibitors of apoptosis [161164]