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Polymorphisms in genes encoding enzymes and transporters essential for creatine metabolismsuch as L- arginine:glycine amidinotransferase ( AGAT ), guanidinoacetate methyltransferase ( GAMT ), and the creatine transporter SLC6A8 have been identified as key determinants of inter-individual differences in creatine homeostasis and therapeutic efficacy [76]

J Am Soc Anesthesiol 99:138147 Villarreal CF, Santos DS, Lauria PS, Gama KB, Esprito-Santo RF, Juiz PJ, Alves CQ, David JM, Soares MB (2020) Bergenin reduces experimental painful diabetic neuropathy by restoring redox and immune homeostasis in the nervous system

The use of the guidelines (GINA) have improved the treatment of many patients, however, treatment options are still limited compared to the heterogeneous mix of pathobiological mechanisms involved in the disease

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