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According to the working model, these cysteine residues may undergo chemical modification/remodeling including trisulfide bond formation and/or related reactions, resulting in a regional (minor, but effective) structural alteration that enhances c-met binding and the nitration resistance of Y198-HGF

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Meanwhile, validation of these findings in vivo will be an essential next step towards translating our results into clinical applications

Recent advances in clinical trials of glutamine metabolism inhibitors In the landscape of oncological research, the inhibition of glutamine metabolism has emerged from preclinical studies as a compelling avenue for therapeutic intervention, sparking fervent interest in its clinical application