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The MHRA ( Medicines and Healthcare products Regulatory Agency ) has two main application procedures: Simple Reclassification : This is a straightforward and quick procedure based on an analogous product (a medicinal product already on the UK market with the same active ingredient, route of administration, use, and a similar or higher strength/dosage)

It usually ranges from 1 mg to 2.5 mg per shot

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Mice were maintained in one controlled colony room, kept at 2123 C and 4550% humidity with a 12-h lightdark cycle (lights on 6 a.m.6 p.m

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