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20 We used two separate study designs and cohorts to address our objectives: (1) to assess time trends in prevalence of smoking, we used a serial cross-sectional design of HRS waves 19982018

Ibid., para 217

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Nevertheless, these data together paint a smoker epithelium that has been rendered more functionally monochromatic, collapsing on the secretory and proteosomal basal cell phenotypes at the expense of its normal defensive, interactive, and reparative roles essential to lung health and homeostasis

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