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Knockdown of GATA2 decreased CGA expression and attenuated chemoresistance, while addition of rCGA overcame the effect of GATA2 knockdown (Figure 5, E and F, and Supplemental Figure 7B)

10.1016/j.fct.2014.03.018 459 van BergenJ

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Polyphenols have the potential to suppress the development of cancer cells through various mechanisms, including interfering with the signaling of growth factor receptors and the cell cycle progression, modulating phosphodiesterase, promoting cellular differentiation and cyclooxygenase pathways, and inhibiting cell signaling kinases