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3 Biomedical Research Institute, Lifeliver Co Ltd, Yongin, Korea, Republic of Background: Severe aplastic anemia (SAA) is a rare and potentially fatal disease that is characterized by an immune-mediated functional impairment of hematopoietic stem cells (HSCT), with peripheral blood stem cell transplantation (PBSCT) or bone marrow transplantation (BMT), is the treatment of choice for young patients who have a matched related donor (MRD)
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To further explore the role of intact PIP signalling, we also analysed fibroblasts derived from a patient with CharcotMarieTooth disease type 4B3 (CMT4B3), caused by mutations in MTMR5/SBF1 and associated with mitochondrial dysfunction and disrupted PIP signalling [manuscript under revision, 35,36,37 , a pathway in which Myo-Ins plays a key role as a metabolic precursor