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Description

Altered redox homeostasis in steroid-depleted follicles attenuates hcg regulation of follicular events: Cross-talk between endocrine and igf axis in maturing oocytes

The first step is to react commercially available IR-780 iodide with excess anhydrous piperazine in anhydrous N , N -dimethyl formamide at 85 C to form cyanine-piperazine (CP)

These authors found that toxic IAPP oligomers initially appear within the granules in the secretory pathway, where they disrupt the membranes of the granules, leading to their release into the cytoplasm