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FPM reduced oxidative stress but did not impact intestinal barrier integrity in C

Virtually almost all IDH1 and IDH2 mutations are missense mutations located at R132 and R172, respectively

We reproduced this potentially reversible response by human adult mature OLs in both dissociated cell culture and microfibre ensheathment assays, using an array of insults implicated in MS pathogenesis including the pro-inflammatory molecules interferon (IFN)- and tumor necrosis factor (TNF)-, the excitatory neutrotransmitter glutamate, and metabolic stress conditions involving nutrient deprivation and low glucose 19,42

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The honest answer, which no one in this conversation has commercial incentive to give you, is that we dont fully understand the mechanism yet, the risk is real but narrower than headlines suggested, and diet quality is a more meaningful variable than the presence or absence of grain