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Acknowledgements Research in the Quintana lab is supported by grants NS102807, ES02530, ES029136, AI126880 and AI149699 from the NIH

Luo H, Shan X, Wu J

Rorer, Inc) in the cat

Primers are listed in Supplementary Table 5

Some channels belong to the group of the ligand-gated channels, which requires the binding of a ligand to the receptor region to modify their conformation and be opened or closed (145, 146)