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In particular, GPC-1 is located within the caveolae, where it interacts with eNOS and other flux-regulated signaling molecules (34)

doi: 10.3389/fnagi.2022.885500 Received 28 February 2022 Accepted 30 May 2022 Published 20 June 2022 Volume 14 - 2022 Edited by Nor Azian Abdul Murad, UKM Medical Molecular Biology Institute, Malaysia Reviewed by Ching-Chi Chiu, Chang Gung University, Taiwan

Differential mechanisms of acquired resistance to insulin-like growth factor-i receptor antibody therapy or to a small-molecule inhibitor, BMS-754807, in a human rhabdomyosarcoma model