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The incidence of treatment-related adverse events (trAEs) was set as the major measure for the safety outcome

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The sensors exploit a four-domain fusion protein in which a nuclear receptor of interest is inserted in a loop region of the non-splicing Mtu RecA intein

We have shown that cultured vaginal epithelial cells (VEC) respond to yeast infections by activation of toll-like receptors which initiate intracellular signal transduction pathways that can induce production and secretion of pro-inflammatory cytokines [1]