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Modulation of the latter represents an innovative approach to therapeutic intervention in diseases

Notably, the small number of DEGs identified in males did not cluster into any meaningful pathways

366 The primary mitochondrial diseases caused by nDNA mutations Given that the majority of mitochondrial proteins are encoded by nDNA, mitochondrial diseases resulting from nDNA mutations encompass not only disturbances in OXPHOS but also defects in various structural or functional proteins essential for mtDNA maintenance, mitochondrial function and structure, and mito-nuclear communication

doi: 10.1016/j.clnesp.2023.11.015 75 RossiMJohnsonDWMorrisonMPascoeEMCoombesJSForbesJMet al

These examples underscore the varied amino acid needs that different cell types encounter in vivo