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However, many doctors do not view glutathione as a "foreign" substance in the same way they might view a synthetic drug

Abbreviations AADvac-1 : Active immunotherapy vaccine-1 ACH : Amyloid-cascade hypothesis AD : Alzheimers disease ADDLs : A-derived diffusible ligands ADNP : Activity dependent neuroprotective protein : AP-90 Alzheimer Pathology 90 APH1 : Anterior pharynx defective 1 APLP1 and APLP2 : APP-like proteins 1 and 2 APP : Amyloid precursor protein ART : Amyloid reduction therapy A : Amyloid-beta AD : Amyloid dimer) AFs : Amyloid fibrils AM : Amyloid monomer AO : Amyloid oligomer APF : Amyloid protofibril BACE1 : Beta-site APP cleaving enzyme 1 BBB : Blood Brain Barrier : BiP Binding immunoglobulin protein Ca2 + -CaN : Calcineurin CAA : Cerebro-vasculature cdk-5 : Cyclin-dependent kinase CHC : Central hydrophobic core CNS : Central nervous system CSF : Cerebrospinal Fluid CTFs : C-terminal fragments Fc : Ferrocenoyl GAPDH : Glyceraldehyde-3-Phosphate Dehydrogenase GHK-Cu : Glycyl-L-histidyl-L-lysine Copper GHK-Cu : Glycyl-L-histidyl-L-lysine-copper GPE : Gly-Pro Glu GRP78 : Glucose-regulated protein 78 Gsk3 : Glycogen synthase kinase 3 HDACs : Histone deacetylase Hsp : Heat shock proteins iAb5p : Ac-Leu-Pro-Phe-PheAsp-NH2 IDE : Insulin Degrading Enzyme LRP1 : Lipoprotein receptor-related protein-1 MARK : Microtubule affinity-regulating kinase MMPs : Metalloproteinases NAP : Neuroprotective Peptide NF-kB : Nuclear Factor-kB NFTs : Neurofibrillary tangles NMDA : N-methyl-D-aspartate ODT : Oral disintegrating tablets PEN-2 : Presenilin enhancer 2 P-gP : P-glycoprotein PS1 : Presenilin 1 RAGE : Receptor for Advanced Glycation End-Products ROS : Reactive Oxygen Species) STEP : Striatal-enriched protein tyrosine phosphatase TFP5: Truncated 24-aa peptide tTG : Tissue transglutaminase : WT Wildtype References Aileen Funke S, Willbold D (2012) Peptides for therapy and diagnosis of Alzheimers disease

M.SaricA.ShillidayR

University of Texas MD Anderson Cancer Center, US

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