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Alpha-lipoic acid has also been shown to inhibit replication of HIV in vitro and, in AIDS patients, might improve blood antioxidant status and increase T-helper lymphocyte counts [1]

however, their effectiveness in patients with DN has not been determined

this pathway will, in turn, upregulate pro-fibrogenic matrix metalloproteinase-2 (MMP2) and downregulate matrix metalloproteinase-1 (MMP1), two enzymes responsible for remodeling the hepatic extracellular matrix [9, 191, 192, 216]

The exposed group showed lower methylation levels for all three genes compared to controls, with methylation levels negatively correlated with markers of cytogenetic damage

After the treatment for 2 weeks, the mice were sacrificed, and spleens were collected and digested to prepare single cells suspensions