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Adding NA to pro-inflammatory M1 macrophages increased their efferocytosis and shifted their metabolism toward a more oxidative, M2-like state

In human colon cancer cells, silencing NNMT resulted in approximately a 30% increase in NAD + levels (Xie et al., 2014), whereas NNMT overexpression decreased NAD + levels by 30% (Xie et al., 2014)

Prescription-Only Medicine (POM): Can only be obtained with a valid prescription from an authorised health professional

Pregnant or breastfeeding women should avoid MOTS-c given the absence of safety data in these populations, as is standard for all investigational peptide therapies

When there is any uncertainty about which option to use, consult your pharmacist or healthcare provider before mixing the medication