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The worst viruses, like EBOLA, kill most infected people, but do not spread widely because people get sick quickly and have far fewer contacts

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Their prophylactic efficacy in preventing travelers diarrhea is particularly well established (378, 379), alongside a well-defined beneficial role in managing acute diarrhea in children (380)

Chemotherapy produces predictable, immediate side effectsalopecia, nausea, myelosuppressionbecause rapidly dividing normal cells are collateral damage

Cytosolic free mtDNA can act as a potential DAMP (Figure 2), as it is particularly sensitive to damage by ROS because it lacks histones for mtDNA protection and has no apparent mtDNA repair response (Yakes and Van Houten, 1997)