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IL-1, IL-6, and TNF- can inhibit the synthesis of type II collagen (Col II) and glycosaminoglycans (GAGs,such as Chondroitin sulfate, Keratan sulfate, and Hyaluronic acid) while upregulating the production of cartilage-degrading enzymes such as matrix metalloproteinases (MMP-1, MMP-3, and MMP-13), thereby promoting ECM degradation (127) ( Figure 4 )

Patients with Babesia and Lyme Disease often experience significantly more severe disease and worse outcomes than those experiencing a single infection (15, 16, 17)

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Role of ferroptosis in neuroimmunity and neurodegeneration in multiple sclerosis revealed by multi-omics data

Compounds were formulated with 10% DMSO and 10% Tween-80, and vortexed to obtain a uniform mixture