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In general, replications of the PD-microbiome instances are often poorly developed, presumably as a result of confounding by usage of medication, geographical differences, sequencing methods, and analytical pipelines

861 Menopause is a risk factor for OA, and epidemiological studies have found that postmenopausal women have a rapidly increased risk of osteoarthritis compared to premenopausal women of the same age, indicating that estrogen level is a key factor in OA development

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