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substituted is intended to mean that one or more hydrogen atoms in the group indicated is replaced with one or more independently selected suitable substituents, provided that the normal valency of each atom to which the substituent/s are attached is not exceeded, and that the substitution results in a stable compound

Nelson, Comparison of T1 and T2 metabolite relaxation times in glioma and normal brain at 3T, J

If you are experiencing burning or pain in conjunction with darker urine, this could be a sign of a urinary tract infection (UTI)

Moreover, the risk of vitamin B12 deficiency also increases with increased metformin dose and duration of its use