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The findings of the present study are consistent with those of many previous reports, which have provided evidence that SA has anti-secretagogue, anti-ulcer, and gastroprotective activity in ethanol-induced GUs in rats ( 2 ) are produced by neutrophils that react with lipids to produce lipid peroxidation ( 2 ) and ROS, and depletion of antioxidant enzymes caused by scavenging by the superoxide radical anion (O 2 ) and ROS ( The Nrf2/HO-1 signaling pathway plays a crucial role in protecting cells from oxidative-stress-induced injuries by restoring endogenous antioxidant enzymes (GSH, CAT, and HO-1) ( Our histopathological findings further confirmed that ulcerated tissues display erosion of gastric wall mucous barriers with hemorrhagic lesions, extensive edema, and leukocyte infiltration of the submucosal layer

Lancet 389:528537 [DOI] [PubMed] [Google Scholar] Weinblatt ME, Coblyn JS, Fox DA, Fraser PA, Holdsworth DE, Glass DN, Trentham DE (1985) Efficacy of low-dose methotrexate in rheumatoid arthritis

Morales and Munn-Bosch, 2016)

Control of sulfur partitioning between primary and secondary metabolism