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It is naturally produced by your body and supplementation simply replenishes and optimises levels

Interestingly, the MPLA-induced antimicrobial phenotype does not rely on mitochondrial ROS, which are actively modulated through induction of mitochondrial antioxidants including superoxide dismutase 2 (SOD2), heme oxygenase-1 (HO-1) and glutathione

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Long-term follow-up data from the APOLLO extension study indicate generally favorable tolerability profiles over multiple years, with sustained TTR suppression and manageable safety signals, although concerns regarding peripheral edema and hepatic enzyme elevations warrant ongoing monitoring [140]

Wong BW, Marsch E, Treps L, Baes M, Carmeliet P