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When consuming high-fat foods, SREBP-2 is activated and binded to sterol regulatory elements, thereby affecting the expression level of HMG-CoAR (Langston et al., 2005)

however, similar effects could not be demonstrated for the cells exposed to L-carnitine in vivo

Keyword combinations included viral pneumonia, Traditional Chinese Medicine, natural products, inflammation, and oxidative stress, in addition to mechanism-related terms such as NF-B, Nrf2, PI3K/Akt, MAPK, and NLRP3 inflammasome. Natural compounds acting on these pathways have been shown to suppress cytokine storms, reduce reactive oxygen species accumulation, preserve alveolar epithelial integrity, and alleviate pulmonary inflammation

Excessive alcohol consumption can deplete glutathione reserves, impair liver function, and hinder detoxification

In skeletal muscle, these circulating FFAs promote intramyocellular lipid accumulation, disrupting insulin-stimulated glucose uptake through ceramide-mediated inhibition of Akt phosphorylation (376, 377)