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KYNA can confer protection against excitotoxicity via glutamatergic antagonism, yet excessive levels may simultaneously impair cholinergic signalling through 7nAChRs, contributing to mood and cognitive dysfunction

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The new research, which was conducted with Schistosoma maintained in laboratory conditions, shows that an oxadiazole compound was effective in inhibiting a crucial worm enzyme, called thioredoxin glutathione reductase (TGR)

Mitochondrial dysfunction has been recognized as an early pathogenic event for ASD [354] and AD [355], which significantly impairs brain function, as we discuss above