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Acetaminophen (paracetamol), once widely used for OA-related pain, is now considered a second-line agent due to its modest analgesic efficacy and potential for hepatotoxicity at higher doses

Therefore, elevated UGCR may reflect the combined effects of renal tubular injury and oxidative stress, and thus cannot be considered a specific indicator of ferroptosis in isolation

In general, plant-derived strains are most suitable for use as starter cultures since they are more resistant to plant components such as polyphenol (Lee and Paik, 2017)

H.JuW.et al (2018)

Bjrnsson ES (2021) Clinical management of patients with drug-induced liver injury (DILI)