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It is possible that the observed actions occurred through a complex signaling mechanism that involves the PI3K (Phosphoinositide 3-kinases) and AMPK (AMP-activated protein kinase) pathways

NSAIDs also have harmful effects on the liver, kidneys, GI tract and cardiovascular system, while steroids can affect blood sugar levels and cause weight gain, exacerbating metabolic issues that contribute to knee OA

is supported by the Wellcome Trust Centre for Neuroimaging and has an institutional research agreement with and receives support from Siemens Healthcare