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In contrast, under oxidative stress, KEAP1 releases abundant Nrf2 and subsequently Nrf2 transactivates HO-1, functioning in cytoprotective defense (Chiang et al., 2018)

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(2000) Physiological functions of thioredoxin and thioredoxin reductase, Eur

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Sarbaziha, R., & Goldberg, D

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The Nrf2 protein, encoded by the NFE2L2 gene, regulates around 250 genes that play a role in maintaining cellular balance, including antioxidant proteins, detoxifying enzymes, drug transporters, and various cytoprotective proteins [43]

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Genetic screening is advisable before initiation in at-risk populations

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