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& Tu, C.-L

Nigam et al

Peptide risks Product quality: No FDA oversight means quality varies Underdosed or contaminated products exist Need to source from reputable vendors Third-party testing essential Long-term unknowns: Limited human data beyond 2-3 years Potential effects on insulin sensitivity Theoretical cancer growth concerns Most risks are theoretical, not proven Practical issues: Daily injections required for most Storage requirements (refrigeration) Learning curve for reconstitution More complex than taking a pill SARM risks Product quality (worse than peptides): Frequent mislabeling (tested products don't match claims) Contamination with other compounds Unknown compound purity Some "SARMs" contain actual steroids Known health risks: Liver toxicity proven in humans Testosterone suppression documented Cardiovascular risks established May never fully recover hormones Practical issues: Bloodwork mandatory (expensive) PCT drugs needed (additional compounds) Can't run consecutive cycles safely Higher chance of permanent damage Winner for risk profile: Peptides have unknown risks, SARMs have proven serious risks

The importance of vesicular glutamate release from axons and its involvement in ischemia-induced myelin damage was recently documented by Doyle et al

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