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This is combined with malonyl-CoA in a 1:3 ratio by 7,2-dihydroxy-4methoxyisoflavanol synthase to form tetrahydroxy chalcone

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In addition, the lack of EAAT2 causes mice to have abnormal social behavior and poor nesting behavior.[ref][ref] Rare mutations in SLC1A3 cause a high risk of glaucoma, pointing to the role of glutamate regulation in the optic nerve.[ref] An SLC1A3 variant found in about one percent of the population increases the risk of Tourette syndrome, indicating that glutamate regulation via EAAT1 is important in Tourettes.[ref] Other rare mutations in EAAT1 cause episodic ataxia and epilepsy

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