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When self-assembling sequences are intended to be conjugated to bioactive sequences (i.e., peptides/proteins capable of modifying cellular behavior like adhesion, proliferation or differentiation), two strategies may be employed: i) synthesis of the entire biomolecule (self-assembling sequence + bioactive sequence) in a single process or ii) conjugation of the two sequences by chemoselective ligation recurring to bio-orthogonal functional groups that can react specifically and under mild conditions to form the final conjugate

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