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Notably, adding a mGluR2/3 antagonist was suggested to inhibit the action of spadin, pointing towards a dependency of spadin on mPFC TREK-1 channels that are possibly linked to mGluR2/3 receptors

Additionally, ferroptosis-induced oxidative stress in the GC microenvironment activates the nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome, triggering IL-1 release and pyroptosis (76)