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Given that AGERAGE signaling is known to activate inflammatory and oxidative pathways 76 , our findings support the interpretation that chronic dietary AGE exposure is associated with testicular redox imbalance

doi:10.1093/ajcp/aqz142

Oxidative DNA damage Reactive oxygen species, especially OH radical generated during oxidative stress, can react with and cause modifications in all the components of the DNA molecule (the purine and pyrimidine bases and deoxyribose sugar backbone), causing damage such as base or sugar lesions, single-strand breaks, double-strand breaks, abasic site formation and DNADNA or DNAprotein cross-links [3,53,75]