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Buxbaum, 2015

Steatosis, hypertrophy, and inflammation was scored according to the criteria reported by Liang et al., 2014

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However, administration of exogenous control activators such as nigericin or ATP to infected cells immediately triggered the formation of the NLRP3 inflammasome and the subsequent release of substantial amounts of mature IL-1 (Pachathundikandi et al., 2020)

The advantage of this approach is our ability to exploit the natural ability of cells to create hundreds of thousands of antibodies and select the ones with the strongest affinity for their target(s), to block or to activate them