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Interestingly, the gut metabolic module aspartate degradation I, which converts L-aspartate to oxaloacetate by aspartate aminotransferase, was elevated in SAD patients and the authors hypothesized that bacterial aspartate aminotransferase enzyme activity may represent a link between gut microbiome function and the tryptophan-kynurenine pathway, a key physiological system in psychiatric disorders (Butler et al., 2023)

doi: 10.1172/jci32741 200 RidkerPMPradhanAMacFadyenJGLibbyPGlynnRJ

Jitteriness, anxiety, or heart palpitations are not normal and suggest either excessive caffeine intake combined with the B12 surge, histamine sensitivity producing an adrenaline-like response, or an underlying thyroid or adrenal condition amplified by the metabolic boost

According to our previous study, LAT1 (standing for L-type Amino acid Transporter 1) is indispensable for transport of essential amino acids, general amino acid homeostasis, and consequently, tumor growth ( system, an exchanger that imports cystine, the oxidized form of cysteine, and exports glutamate

(4672:) PMS2CL protein [Homo sapiens]