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These chemicals might impair gametogenesis and gonadal steroidogenesis, leading to infertility ( Oxidative Stress: Increased oxidative stress induced generation of reactive oxygen species (ROS), which results in lipid peroxidation, fragmentation of sperm DNA, and infertility ( DNA Damage and Epigenetic Changes: Changes in gene expression and DNA methylation result in male infertility because of sperm DNA alteration brought on by the creation of DNA adducts, particularly with exposure to PAHs ( Endocrine-disruptor chemicals Many chemical compounds commonly used in daily life have the potential to impact the vertebrate neuroendocrine system, which plays a crucial role in maintaining homeostasis and regulating essential processes such as development, growth, metabolism, and reproduction ( Effect of endocrine disruptors on sperm quality Several studies have provided substantial evidence that EDCs can mimic or block steroid hormones by acting as their agonists or antagonists, disturbing normal hormone-regulated processes, particularly those related to sexual development and reproduction ( in-vivo and in-vitro studies have reported the presence of many substances with estrogenic, anti-estrogenic, androgenic, and anti-androgenic properties ( Figure 1 illustrates the main points where EDCs exsert their influence

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10.2147/JPR.S317204 50 ZhaoL.TaoX.SongT

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Food & Function , 12 (22), 1125011261