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Not much information about their formation in humans is available but a study showing the metabolism of pivalic acid (a component of Pivaloyloxyethyl, a prodrug of methyldopa) via the acyl CoA formation pathway and not by glucuronidation, as seen in rats, monkeys and rabbits, suggests that humans might be particularly susceptible (120)

G., Turner,B

Eye Res 74 , 245254

HTLV-1 infection acts as a tumorigenic factor through epigenetic regulation Adult T-cell leukemia/lymphoma (ATLL) is a rare and aggressive T-cell lymphoma known for its elevated levels of H3K27me3