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For instance, amifostine exhibits remarkable individual differences in efficacy and toxicity: it requires alkaline phosphatase (ALP) for conversion in vivo to exert its effects, and varying ALP levels among tumor patients affect the production of its active metabolites, thereby influencing therapeutic efficacy (192)

Ovariectomy and subsequent treatment with estrogen receptor agonists tune the innate immune system of the hippocampus in middle-aged female rats

Such oxidative stress directly impacts neurotransmitter turnover and receptor function, thereby linking redox imbalance with neurotransmitter dysregulation and potential cognitive deficits (Kumar et al

If there is a complete tear within the muscle, the torn ends are reattached using stitches

Some patients experience fluid retention, particularly early in the protocol