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[7] That preclinical promise carried the compound into a human Phase II program for postoperative ileus but the randomized, placebo-controlled trial in bowel-resection patients did not meet its primary efficacy endpoint, and clinical development was subsequently discontinued

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HEK-293T were from American Type Culture Collection (ATCC), and cultured in Dulbeccos modified Eagles medium (DMEM) (Cytiva, SH30003.02) supplemented with 10% fetal bovine serum (FBS, Cytiva)

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6.5 Corneal disorders Studies have demonstrated that decreased levels of GPX4 in HCECs can lead to increased LDH levels, which can trigger ferroptosis (150)