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Oncogene (2007) 26(56):77418

Vascular cell adhesion protein-1 (VCAM-1) is involved in the adhesion of lymphocytes, eosinophils, and basophils to the vascular endothelium and is an essential mediator in developing atherosclerosis and DM

PAMORAs, such as methylnaltrexone, naldemedine, and naloxegol 36,37,38 , can effectively alleviate opioid-induced constipation by selectively blocking MORs in the enteric nervous system without affecting central opioid analgesia 10,21