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Referral triggers include persistent hyperglycemia despite therapy, suspected pancreatitis, acute kidney injury, gallbladder disease, or concerning cardiovascular symptoms

Similalry, significant improvement in the vitamin C content by the overexpression of some biosynthetic genes has been practically achieved in tomato, potato, lettuce and strawberry (Zhang et al., 2011

B12 supplementation addresses the nutrient depletion that can occur with reduced food intake and altered absorption

Technology appraisal guidance [TA352]

[2] Research indicates that ALA may improve symptoms of diabetic neuropathy: for example, clinical trials and meta-analyses have shown that intravenous ALA (typically 600 mg per day for 3 weeks) may significantly reduce neuropathic pain, paresthesia, and numbness in diabetic patients