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NAC is a potent antioxidant and anti-inflammatory agent, clinically used to counteract oxidative stress, reduce lung fibrosis, and ameliorate silica-induced inflammation in experimental silicosis models

Currently, more and more global medical societies recommend consuming a wide range of dietary supplements throughout pregnancy [178,179,180,181,182,183] (Table 1)

While in many mammalian species UA is further degraded to allantoin, in humans and certain other primates the uricase activity responsible for this metabolic removal has been lost

To this end, we overexpressed the murine cystine/glutamate antiporter xCT (Slc7a11) in Pfa1 cells (Extended Data Fig