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Following alleviation of diabetic symptoms, Metformin leads to the reduction of AGEs and inflammatory mediators such as phosphorylated NF-B 63

Kzlay F, Altay B

Besides well-known oxidants or electrophiles, such as H 2 O 2 , 4-hydroxynonenal, and diethyl maleate (DEM), which also possess cytotoxicity, only few Nrf2 activators have been found to be useful in clinical trials (Sun et al