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However, nanomaterials are still in the early stages of clinical application for brain tumors, and there is still a long way to go, since nanomaterials degradation behavior and excretion pathways are still unclear, and there are numerous differences among patients and difficulties in reproducing results

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HR=1.72, 95% CI 1.09-2.72)

Together with its role in glutamate excitotoxity, NO could contribute to oxidative stress mechanisms in the pathogenesis of PD by interacting with ferritin to release iron, inducing mitochondrial complex I damage (Molina et al., 1998), and by inducing nitrosylation of proteins (Fernndez et al., 2013)