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We will continue to engage with interested parties to assess the appropriate level of code stratification and will address any potential refinements through future rulemaking

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Secondary metabolic markers include fasting glucose, insulin sensitivity via HOMA-IR or glucose tolerance testing, body composition changes (DEXA scan or MRI for fat mass and lean mass distribution), mitochondrial respiration capacity via Seahorse analyzer, and serum markers like HbA1c for long-term glucose control

Understanding the differences in classification among all opioid classes has implications for clinicians, as differences in chemical structures result in varying receptor affinities, potencies, pharmacokinetic characteristics, and risk profiles (6)(7)(51)