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In addition, the effect of glycolysis inhibitors may also be enhanced by high-dose VitC in a ROS-dependent manner, since both inhibitors increase oxidative stress levels [235]

Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA

First, structural data with the aldehyde derivative of UNC10088 reveal a conformational change in FBXO22 that further exposes the reactive cysteine, C326