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3C, Table S7)

Notably, the direction of effect estimates remains consistent with those in primary analysis for all 56 RI-associated CpGs, and in the adjusted model, the P- values for RI remained significant, ranging from 0.034 to 3.0 10 10 (Supplementary Table 18)

Beyond acute neuroprotection, these compounds may support long-term rehabilitation by enhancing synaptic remodeling and cognitive resilience (Figure 2)